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Food withdrawal alters the gut microbiota and metabolome in mice.

ABSTRACT: Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolome. The abundance of potentially pathogenic Proteobacteria was decreased and Akkermansia muciniphila was elevated by food withdrawal in mice fed a high-fat diet (HFD). Meanwhile, food withdrawal decreased the abundance of metabolites in branched chain amino acid, lipid, and free fatty acid metabolisms in host serum, more so in HFD mice than in normal mice. Microbial predicted function also showed that food withdrawal decreased the abundance of microbes associated with predicted diseases in the HFD group but not in the normal chow group. Correlation between the microbiome data and metabolomics data revealed a strong association between gut microbial and host metabolic changes in response to food withdrawal. In summary, our results showed that food withdrawal was safer and more metabolically beneficial to HFD-induced obese mice than to normal lean mice, and the beneficial effects were primarily derived from the changes in gut microbiota, which were closely associated with the host metabolome.-Zheng, X., Zhou, K., Zhang, Y., Han, X., Zhao, A., Liu, J., Qu, C., Ge, K., Huang, F., Hernandez, B., Yu, H., Panee, J., Chen, T., Jia, W., Jia, W. Food withdrawal alters the gut microbiota and metabolome in mice.

SUBMITTER: Zheng X

PROVIDER: S-EPMC9292403 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Food withdrawal alters the gut microbiota and metabolome in mice.

Zheng Xiaojiao X Zhou Kejun K Zhang Yunjing Y Han Xiaolong X Zhao Aihua A Liu Jiajian J Qu Chun C Ge Kun K Huang Fengjie F Hernandez Brenda B Yu Herbert H Panee Jun J Chen Tianlu T Jia Weiping W Jia Wei W

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180405 9

Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolom ...[more]

PMID: 29620942

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Food withdrawal alters the gut microbiota and metabolome in mice.

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Food withdrawal alters the gut microbiota and metabolome in mice.

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