Postprandial rise of essential amino acids is impaired during critical illness and unrelated to small-intestinal function.

ABSTRACT:

Background

Postprandial rise of plasma essential amino acids (EAAs) determines the anabolic effect of dietary protein. Disturbed gastrointestinal function could impair the anabolic response in critically ill patients. Aim was to investigate the postprandial EAA response in critically ill patients and its relation to small-intestinal function.

Methods

Twenty-one mechanically ventilated patients and 9 healthy controls received a bolus containing 100 ml of a formula feed (Ensure) and 2 g of 3-O-Methyl-d-glucose (3-OMG) via postpyloric feeding tube. Fasting and postprandial plasma concentrations of EAAs, 3-OMG, total bile salts, and the gut-released hormone fibroblast growth factor 19 (FGF19) were measured over a 4-hour period. Changes over time and between groups were assessed

SUBMITTER: van Gassel RJJ 

PROVIDER: S-EPMC9293041 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature