Shortening the Haemophilia Activities List (HAL) from 42 items to 18 items.

ABSTRACT:

Introduction

The Haemophilia Activities List (HAL) was developed to measure activities and participation in persons with haemophilia (PWH). Shortening the questionnaire may facilitate use of the HAL.

Aim

The aim of this study was to determine which items of the HAL are redundant, to construct a shorter version of the HAL, and to determine the construct validity of the HAL_short .

Methods

A secondary analysis was performed on pooled data of two published studies using the HAL (seven domains, 42 items, optimum score: 100) in adults with haemophilia A/B. Data were divided into a derivation (62%) and a validation set (38%). Redundant items were identified by evaluation of: floor and ceiling effects, proportions of missing and 'not applicable' responses, inter-item correlations, component loadings in an exploratory factor analysis, internal consistency, and item-total correlations. Correlations with the SF-36 and EQ-5D-5L were used to determine construct validity of the HAL_short .

Results

Data on 680 PWH were evaluated. In the derivation dataset (n = 420), median age was 30 years (range 18-80), 43% had severe haemophilia and 61% received prophylaxis. Median (IQR) HAL sum score was 65.0 (55.7-88.8). The stepwise procedure resulted in a HAL_short of 18 items with a median sum score of 63.3 (54.4-86.7). Construct validity was similar for the HAL and HAL_short in the validation dataset (n = 260).

Conclusion

This clinimetric study resulted in a >50% shortening of the HAL. The 18-item HAL_short reduces patient burden and is expected to capture the information on activities and participation. The HAL_short needs further validation.

SUBMITTER: Kuijlaars IAR 

PROVIDER: S-EPMC9293145 | biostudies-literature |

REPOSITORIES: biostudies-literature