Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions.

ABSTRACT:

Background

Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion in large body areas using laser speckle contrast imaging (LSCI).

Objectives

To (i) assess whether increased perilesional perfusion and perfusion inhomogeneity are predictors for expansion of psoriasis lesions and (ii) assess feasibility of the HAPI system in a mounted modality.

Methods

In this interventional pilot study in adults with unstable plaque psoriasis, HAPI measurements and color photographs were performed for lesions present on one body region at week 0, 2, 4, 6 and 8. The presence of increased perilesional perfusion and perfusion inhomogeneity was determined. Clinic

SUBMITTER: Schaap MJ 

PROVIDER: S-EPMC9293292 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature