Ontology highlight
ABSTRACT:
SUBMITTER: Igarashi N
PROVIDER: S-EPMC9293948 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Igarashi Nanase N Miyata Kenichi K Loo Tze Mun TM Chiba Masatomo M Hanyu Aki A Nishio Mika M Kawasaki Hiroko H Zheng Hao H Toyokuni Shinya S Kon Shunsuke S Moriyama Keiji K Fujita Yasuyuki Y Takahashi Akiko A
Nature communications 20220718 1
Cellular senescence and cell competition are important tumor suppression mechanisms that restrain cells with oncogenic mutations at the initial stage of cancer development. However, the link between cellular senescence and cell competition remains unclear. Senescent cells accumulated during the in vivo aging process contribute toward age-related cancers via the development of senescence-associated secretory phenotype (SASP). Here, we report that hepatocyte growth factor (HGF), a SASP factor, inh ...[more]