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ABSTRACT:
SUBMITTER: Hansen T
PROVIDER: S-EPMC9295157 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Hansen Thomas T Vermeeren Pascal P de Jong Lea L Bickelhaupt F Matthias FM Hamlin Trevor A TA
The Journal of organic chemistry 20220624 14
We have quantum chemically explored the competition between the S<sub>N</sub>2 and S<sub>N</sub>2' pathways for X<sup>-</sup> + H<sub>2</sub>C═CHCH<sub>2</sub>Y (X, Y = F, Cl, Br, I) using a combined relativistic density functional theory and coupled-cluster theory approach. Bimolecular nucleophilic substitution reactions at allylic systems, i.e., C<sup>γ</sup>═C<sup>β</sup>-C<sup>α</sup>-Y, bearing a leaving-group at the α-position, proceed either via a direct attack at the α-carbon (S<sub>N</s ...[more]