Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults.

ABSTRACT:

Background

Component-resolved diagnostics (CRD) help predict hazelnut allergy (HA) in children, but are of unknown diagnostic value in adults. This study aimed to evaluate the diagnostic accuracy of IgE to hazelnut extract and components in adults.

Methods

A Dutch population of consecutively presenting adults suspected of HA, who underwent a double-blind placebo-controlled food challenge, were included. Serum IgE to hazelnut extract and Cor a 1, 8, 9, and 14 was measured on ImmunoCAP. Diagnostic accuracy was assessed by area under the curve (AUC) analysis.

Results

Of 89 patients undergoing challenge, 46 had challenge-confirmed HA: 17 based on objective and 29 based on subjective symptoms. At commonly applied cutoffs 0.1 and 0.35 kU_A /L, high sensitivity was

SUBMITTER: Lyons SA 

PROVIDER: S-EPMC9298907 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature