Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa.

ABSTRACT:

Objective

Plasma thrombin generation (TG) provides important information on coagulation status; however, current TG output parameters do not predict major bleeding of patients on anticoagulants. We recently reported that factor V (FV) activation by factor X (FX)a contributes importantly to the initiation phase of TG. Here we investigated how this pathway varies in the normal population and whether FXa-mediated activation of FV is associated with major bleeding in patients on anticoagulant therapy.

Approach

We employed TIX-5, a specific inhibitor of FV activation by FXa, to estimate the contribution of FXa-mediated FV activation to tissue factor (TF)-initiated TG.

Results

We show that the contribution of this pathway to plasma TG varies considerably in the normal popul

SUBMITTER: Maag A 

PROVIDER: S-EPMC9299225 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature