Is TIMP-1 a biomarker for periodontal disease? A systematic review and meta-analysis.

ABSTRACT:

Objective

One of the most important families of proteases associated with periodontal disease is the family of the matrix metalloproteinases (MMPs). Their activity is regulated by tissue inhibitors of metalloproteinases (TIMPs), and an imbalance between MMP activity and regulation by TIMPs has been associated with the progression of periodontal disease. This strong interaction between TIMPs and MMPs might be an indication that TIMPs can be used as a biomarker to monitor periodontal disease progression in oral fluids. In particular, TIMP-1 is a frequently studied biomarker for periodontal diseases. Therefore, the aim of this systematic review was to evaluate the scientific literature regarding TIMP-1 concentrations in oral fluids of patients suffering from periodontitis or gingiviti

SUBMITTER: de Brouwer P 

PROVIDER: S-EPMC9299605 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature