Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.
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ABSTRACT:
SUBMITTER: Font-Porterias N
PROVIDER: S-EPMC9299678 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.
Font-Porterias Neus N McNelis Madeline G MG Comas David D Hlusko Leslea J LJ
Integrative organismal biology (Oxford, England) 20220719 1
<h4>Synopsis</h4>The ectodysplasin pathway has been a target of evolution repeatedly. Genetic variation in the key genes of this pathway (<i>EDA</i>, <i>EDAR</i>, and <i>EDARADD</i>) results in a rich source of pleiotropic effects across ectodermally-derived structures, including teeth, hair, sweat glands, and mammary glands. In addition, a non-canonical Wnt pathway has a very similar functional role, making variation in the <i>WNT10A</i> gene also of evolutionary significance. The adaptation of ...[more]
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