Systematic review of associations between HLA and renal function.

ABSTRACT:

Introduction

Kidney dysfunction is a highly significant disease, both in the United Kingdom and globally. Many previous studies have reported associations between human leukocyte antigens (HLA) and renal function; this systematic review attempts to identify, summarize and appraise all published studies of these associations.

Methods

A literature search was performed using Medline, Embase and Cochrane Central Register of Controlled Trials to identify papers whose keywords included each of the following concepts: HLA, renal failure and genetic association. A total of 245 papers were identified and assessed for eligibility; 35 of these were included in the final study.

Results

A total of 95 HLA types and 14 three-locus haplotypes were reported to be associated with eithe

SUBMITTER: Lowe M 

PROVIDER: S-EPMC9300076 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature