Unknown

Dataset Information

0

Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity.


ABSTRACT: A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Additionally, the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency.

SUBMITTER: Che C 

PROVIDER: S-EPMC9301648 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2918871 | biostudies-literature
| S-EPMC8346139 | biostudies-literature
| S-EPMC7126098 | biostudies-literature
| S-EPMC5996720 | biostudies-literature
| S-EPMC8318836 | biostudies-literature
2022-12-13 | GSE198400 | GEO
| S-EPMC4073672 | biostudies-literature
| S-EPMC8293910 | biostudies-literature
| S-EPMC6641749 | biostudies-literature
| S-EPMC7109937 | biostudies-literature