Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources.

ABSTRACT: Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M. hominis is the most commonly reported to play a role in systemic infections and can persist in the host for a long time. However, it is unclear how M. hominis proceeds under arginine limitation. The recent metabolic reconstruction of M. hominis has demonstrated its ability to catabolize deoxyribose phosphate to produce ATP. In this study, we cultivated M. hominis on two different energy sources (arginine and thymidine) and demonstrated the differences in growth rate, antibiotic sensitivity, and biofilm formation. Using label-free quantitative proteomics, we compared th

SUBMITTER: Evsyutina DV 

PROVIDER: S-EPMC9301678 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature