Comparison of sampling methods for next generation sequencing for patients with lung cancer.

ABSTRACT:

Introduction

Success of next generation sequencing (NGS) analysis is becoming indispensable in the treatment of advanced lung cancer. However, the advantages and disadvantages of each sampling method in the NGS analysis have not yet been clarified.

Methods

We compared the success rates of NGS analysis, and DNA and RNA yields for transbronchial biopsy (TBB), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), computed tomography (CT)-guided biopsy, fluid sample, and surgical biopsy for NGS analysis in patients through the lung cancer genomic screening project for individualized medicine (LC-SCRUM)-Asia, a nationwide NGS screening project. In case, sufficient samples could not be collected by TBB and EBUS-TBNA, re-biopsy (genome re-biopsy) was perform

SUBMITTER: Kunimasa K 

PROVIDER: S-EPMC9302352 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature