Impact of CYBA genotypes on severity and progression of multiple sclerosis.

ABSTRACT:

Background and purpose

The NOX2 enzyme of myeloid cells generates reactive oxygen species (ROS) that have been implicated in the pathology of multiple sclerosis (MS). We aimed to determine the impact of genetic variation within CYBA, which encodes the functional CYBA/p22^phox subunit of NOX2, on MS severity and progression.

Methods

One hundred three MS patients with up to 49 (median = 17) years follow-up time from first MS diagnosis were genotyped at the single nucleotide polymorphisms rs1049254 and rs4673 within CYBA. Results were matched with disease severity and time to diagnosis of secondary progressive MS (SPMS). NOX2-mediated formation of ROS was measured by chemiluminescence in blood myeloid cells from healthy donors (n = 55) with defined genotypes at rs1049

SUBMITTER: Tornell A 

PROVIDER: S-EPMC9303184 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature