Overt hepatic encephalopathy is an independent risk factor for de novo infection in cirrhotic patients with acute decompensation.

ABSTRACT:

Background

The occurrence of overt hepatic encephalopathy (OHE) is associated with increased mortality. HE is commonly precipitated by infection, but whether HE predisposes to new infection is unclear. This study aimed to test if OHE predisposes to de novo infection during hospitalisation and its association with short-term mortality.

Aims and methods

Seven hundred and fifty-nine consecutive patients were identified at two institutions from prospectively maintained clinical databases of cirrhotic patients admitted with acute decompensation (AD). Infection and HE data were collected on the day of admission, and the occurrence of de novo infections was assessed for 28 days after admission. EASL-CLIF organ failure criteria were used to determine the presence of organ failures.

SUBMITTER: Alabsawy E 

PROVIDER: S-EPMC9303427 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature