Unknown

Dataset Information

0

The pH-Dependence of the Hydration of 5-Formylcytosine: an Experimental and Theoretical Study.


ABSTRACT: 5-Formylcytosine is an important nucleobase in epigenetic regulation, whose hydrate form has been implicated in the formation of 5-carboxycytosine as well as oligonucleotide binding events. The hydrate content of 5-formylcytosine and its uracil derivative has now been quantified using a combination of NMR and mass spectroscopic measurements as well as theoretical studies. Small amounts of hydrate can be identified for the protonated form of 5-formylcytosine and for neutral 5-formyluracil. For neutral 5-formylcytosine, however, direct detection of the hydrate was not possible due to its very low abundance. This is in full agreement with theoretical estimates.

SUBMITTER: Zott FL 

PROVIDER: S-EPMC9304204 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9146526 | biostudies-literature
| S-EPMC2376230 | biostudies-literature
| S-EPMC5493298 | biostudies-literature
| S-EPMC2426655 | biostudies-literature
| S-EPMC3899642 | biostudies-other
| S-EPMC6895156 | biostudies-literature
| S-EPMC10949015 | biostudies-literature
| S-EPMC6432485 | biostudies-literature
| S-EPMC5592374 | biostudies-other
| S-EPMC3098132 | biostudies-literature