Ontology highlight
ABSTRACT:
SUBMITTER: Schoretsanitis G
PROVIDER: S-EPMC9305461 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Schoretsanitis Georgios G Dubath Céline C Grosu Claire C Piras Marianna M Laaboub Nermine N Ranjbar Setareh S Ansermot Nicolas N Crettol Séverine S Vandenberghe Frederik F Gamma Franziska F von Gunten Armin A Plessen Kerstin Jessica KJ Seifritz Erich E Conus Philippe P Eap Chin B CB
Basic & clinical pharmacology & toxicology 20220217 4
Metabolic abnormalities have been associated with olanzapine treatment. We assessed if olanzapine has dose-dependent effects on metabolic parameters with changes for weight, blood pressure, lipid and glucose profiles being modelled using linear mixed-effects models. The risk of metabolic abnormalities including early weight gain (EWG) (≥5% during first month) was assessed using mixed-effects logistic regression models. In 392 olanzapine-treated patients (median age 38.0 years, interquartile rang ...[more]