Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes.

ABSTRACT:

Introduction/aims

Sonographic alterations of peripheral nerves in pre-dialytic kidney disease are yet to be determined. We aimed to assess peripheral nerve cross-sectional area (CSA) and intraneural blood flow in patients with pre-dialytic chronic kidney disease (CKD) and diabetic kidney disease (DKD).

Methods

Subjects with CKD (n = 20) or DKD (n = 20) underwent ultrasound to assess CSA of the median and tibial nerves as well as intraneural blood flow of the median nerve. Blood flow was quantified using maximum perfusion intensity. Neuropathy was assessed using the Total Neuropathy Score. A 6-m timed walk test was also performed. Healthy controls (n = 28) were recruited for comparison.

Results

The DKD group had more severe neuropathy (p = .024), larger tibial nerve CS

SUBMITTER: Issar T 

PROVIDER: S-EPMC9305967 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature