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Single-particle detection of native SARS-CoV-2 virions by microfluidic resistive pulse sensing

ABSTRACT: Microfluidic resistive pulse sensing (MRPS) was used to determine the size distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on detecting nearly 30 000 single virions. However, the ultrastructure of SARS-CoV-2 is thoroughly described, but ensemble properties of SARS-CoV-2, e.g., its particle size distribution, are sparsely reported. According to the MRPS results, the size distribution of SARS-CoV-2 follows a log-normal function with a mean value of 85.1 nm, which corresponds to an approximate diameter of the viral envelope. This result also confirms the low number (< 50) of spike proteins on the surface of the virions. Graphical Abstract

SUBMITTER: Varga Z

PROVIDER: S-EPMC9306222 | biostudies-literature |

REPOSITORIES: biostudies-literature

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