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Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1.

ABSTRACT: Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, whereas CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: that is, vasopressin, oxytocin, tyrosine hydroxylase, and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, that is, the suprachiasmatic, ventrolateral preoptic, infundibular, and supraoptic nuclei and nucleus basalis of Meynert, were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. ANN NEUROL 2022;91:282-288.

SUBMITTER: Shan L

PROVIDER: S-EPMC9306683 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1.

Shan Ling L Balesar Rawien R Swaab Dick F DF Lammers Gert Jan GJ Fronczek Rolf R

Annals of neurology 20220119 2

Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, whereas CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: that is, vasopressin, oxytocin, tyrosine hydroxylase, and thyrotropin releasing horm ...[more]

PMID: 34981555

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