The role of the ADVanced Organ Support (ADVOS) system in critically ill patients with multiple organ failure.

ABSTRACT:

Background

Multi-organ failure characterized by acute kidney injury, liver dysfunction, and respiratory failure is a complex condition associated with high mortality, for which multiple individual support devices may be simultaneously required. This review aims to appraise the current evidence for the ADVanced Organ Support (ADVOS) system, a novel device integrating liver, lung, and kidney support with blood detoxification.

Methods

We performed a literature review of the PubMed database to identify human and animal studies evaluating the ADVOS system.

Results

In porcine models of acute liver injury and small clinical studies in humans, ADVOS significantly enhanced the elimination of water-soluble and protein-bound toxins and metabolites, including creatinine, ammonia,

SUBMITTER: Acharya M 

PROVIDER: S-EPMC9306712 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature