Inhibition of Osteoblast Differentiation by JAK2^V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis.

ABSTRACT: Past studies described interactions between normal megakaryocytes, the platelet precursors, and bone cell precursors in the bone marrow. This relationship has also been studied in context of various mutations associated with increased number of megakaryocytes. The current study is the first to examine the effects of megakaryocytes from transgenic mice carrying the most common mutation that causes primary myelofibrosis (PMF) in humans (JAK2^V617F) on bone cell differentiation. Organ level assessments of mice using micro-computed tomography showed decreased bone volume in JAK2^V617F males, compared to matching controls. Tissue level histology revealed increased deposition of osteoid (bone matrix prior mineralization) in these mutated mice, suggesting an effect on osteobla

SUBMITTER: Karagianni A 

PROVIDER: S-EPMC9307716 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature