The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors.

ABSTRACT: Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer-associated fibroblasts (CAFs) to feed anabolic cancer cells. These catabolic and anabolic cells make a metabolic compartment through which high-energy metabolites like lactate can be transferred via the monocarboxylate transporter channel 4. Moreover, a decrease in molecules, including caveolin-1, has been reported to cause deep metabolic changes in normal fibroblasts toward myofibroblast differentiation. In this context, metformin is a promising drug in cancer therapy due to its effect on oncogenic signal transduction pathways, leading to t

SUBMITTER: Mostafavi S 

PROVIDER: S-EPMC9308248 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature