Landscape of somatic alterations in large-scale solid tumors from an Asian population.
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ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC9308789 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Landscape of somatic alterations in large-scale solid tumors from an Asian population.
Wu Liqun L Yao Herui H Chen Hui H Wang Aodi A Guo Kun K Gou Wenli W Yu Yanfei Y Li Xiang X Yao Ming M Yuan Shaohua S Pang Fei F Hu Jinwei J Chen Lijuan L Liu Wenjin W Yao Jicheng J Zhang Shuirong S Dong Xiaowei X Wang Weifeng W Hu Jing J Ling Qi Q Ding Songming S Wei Yan Y Li Qiang Q Cao Weichun W Wang Shuang S Di Yang Y Feng Feiling F Zhao Gang G Zhang Jian J Huang Ling L Xu Jia J Yan Wangjun W Tong Zhongsheng Z Jiang Da D Ji Tao T Li Qiao Q Xu Ling L He Huiying H Shang Liang L Liu Jin J Wang Kefeng K Wu Duoguang D Shen Jingnan J Liu Ye Y Zhang Ting T Liang Chaojie C Wang Yusheng Y Shang Yanhong Y Guo Jianji J Liang Guanbiao G Xu Shifeng S Liu Junfeng J Wang Kai K Wang Minghui M
Nature communications 20220723 1
Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tumor tissues and matched blood specimens from over 10,000 patients in China by using a 450-gene comprehensive assay, developed and implemented under international clinical regulations. We perform a comprehensive comparison of somatically altered genes, ...[more]
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