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Antibiotic resistance in Salmonella enterica serovar Typhimurium exposed to microcin-producing Escherichia coli.

ABSTRACT: Microcin 24 is an antimicrobial peptide secreted by uropathogenic Escherichia coli. Secretion of microcin 24 provides an antibacterial defense mechanism for E. coli. In a plasmid-based system using transformed Salmonella enterica, we found that resistance to microcin 24 could be seen in concert with a multiple-antibiotic resistance phenotype. This multidrug-resistant phenotype appeared when Salmonella was exposed to an E. coli strain expressing microcin 24. Therefore, it appears that multidrug-resistant Salmonella can arise as a result of an insult from other pathogenic bacteria.

SUBMITTER: Carlson SA 

PROVIDER: S-EPMC93088 | biostudies-literature | 2001 Aug

REPOSITORIES: biostudies-literature

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Antibiotic resistance in Salmonella enterica serovar Typhimurium exposed to microcin-producing Escherichia coli.

Carlson S A SA   Frana T S TS   Griffith R W RW  

Applied and environmental microbiology 20010801 8

Microcin 24 is an antimicrobial peptide secreted by uropathogenic Escherichia coli. Secretion of microcin 24 provides an antibacterial defense mechanism for E. coli. In a plasmid-based system using transformed Salmonella enterica, we found that resistance to microcin 24 could be seen in concert with a multiple-antibiotic resistance phenotype. This multidrug-resistant phenotype appeared when Salmonella was exposed to an E. coli strain expressing microcin 24. Therefore, it appears that multidrug-r  ...[more]