Dataset Information

Real-time MRI motion estimation through an unsupervised k-space-driven deformable registration network (KS-RegNet).

ABSTRACT: Purpose. Real-time three-dimensional (3D) magnetic resonance (MR) imaging is challenging because of slow MR signal acquisition, leading to highly under-sampled k-space data. Here, we proposed a deep learning-based, k-space-driven deformable registration network (KS-RegNet) for real-time 3D MR imaging. By incorporating prior information, KS-RegNet performs a deformable image registration between a fully-sampled prior image and on-board images acquired from highly-under-sampled k-space data, to generate high-quality on-board images for real-time motion tracking.Methods. KS-RegNet is an end-to-end, unsupervised network consisting of an input data generation block, a subsequent U-Net core block, and following operations to compute data fidelity and regularization losses. The input data involved a fully-sampled, complex-valued prior image, and the k-space data of an on-board, real-time MR image (MRI). From the k-space data, under-sampled real-time MRI was reconstructed by the data generation block to input into the U-Net core. In addition, to train the U-Net core to learn the under-sampling artifacts, the k-space data of the prior image was intentionally under-sampled using the same readout trajectory as the real-time MRI, and reconstructed to serve an additional input. The U-Net core predicted a deformation vector field that deforms the prior MRI to on-board real-time MRI. To avoid adverse effects of quantifying image similarity on the artifacts-ridden images, the data fidelity loss of deformation was evaluated directly in k-space.Results. Compared with Elastix and other deep learning network architectures, KS-RegNet demonstrated better and more stable performance. The average (±s.d.) DICE coefficients of KS-RegNet on a cardiac dataset for the 5- , 9- , and 13-spoke k-space acquisitions were 0.884 ± 0.025, 0.889 ± 0.024, and 0.894 ± 0.022, respectively; and the corresponding average (±s.d.) center-of-mass errors (COMEs) were 1.21 ± 1.09, 1.29 ± 1.22, and 1.01 ± 0.86 mm, respectively. KS-RegNet also provided the best performance on an abdominal dataset.Conclusion. KS-RegNet allows real-time MRI generation with sub-second latency. It enables potential real-time MR-guided soft tissue tracking, tumor localization, and radiotherapy plan adaptation.

SUBMITTER: Shao HC

PROVIDER: S-EPMC9309029 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Real-time MRI motion estimation through an unsupervised k-space-driven deformable registration network (KS-RegNet).

Shao Hua-Chieh HC Li Tian T Dohopolski Michael J MJ Wang Jing J Cai Jing J Tan Jun J Wang Kai K Zhang You Y

Physics in medicine and biology 20220629 13

<i>Purpose</i>. Real-time three-dimensional (3D) magnetic resonance (MR) imaging is challenging because of slow MR signal acquisition, leading to highly under-sampled k-space data. Here, we proposed a deep learning-based, k-space-driven deformable registration network (KS-RegNet) for real-time 3D MR imaging. By incorporating prior information, KS-RegNet performs a deformable image registration between a fully-sampled prior image and on-board images acquired from highly-under-sampled k-space data ...[more]

PMID: 35667374

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Project description:PurposeValidating deformable multimodality image registrations is challenging due to intrinsic differences in signal characteristics and their spatial intensity distributions. Evaluating multimodality registrations using these spatial intensity distributions is also complicated by the fact that these metrics are often employed in the registration optimization process. This work evaluates rigid and deformable image registrations of the prostate in between diagnostic-MRI and radiation treatment planning-CT by utilizing a planning-MRI after fiducial marker placement as a surrogate. The surrogate allows for the direct quantitative analysis that can be difficult in the multimodality domain.MethodsFor thirteen prostate patients, T2 images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day as the planning-CT (planning-MRI). The diagnostic-MRI was deformed to the planning-CT utilizing a commercially available algorithm which synthesizes a deformable image registration (DIR) algorithm from local rigid registrations. The planning-MRI provided an independent surrogate for the planning-CT for assessing registration accuracy using image similarity metrics, including Pearson correlation and normalized mutual information (NMI). A local analysis was performed by looking only within the prostate, proximal seminal vesicles, penile bulb, and combined areas.ResultsThe planning-MRI provided an excellent surrogate for the planning-CT with residual error in fiducial alignment between the two datasets being submillimeter, 0.78 mm. DIR was superior to the rigid registration in 11 of 13 cases demonstrating a 27.37% improvement in NMI (P < 0.009) within a regional area surrounding the prostate and associated critical organs. Pearson correlations showed similar results, demonstrating a 13.02% improvement (P < 0.013).ConclusionBy utilizing the planning-MRI as a surrogate for the planning-CT, an independent evaluation of registration accuracy is possible. This population provides an ideal testing ground for MRI to CT DIR by obviating the need for multimodality comparisons which are inherently more challenging.

Project description:PURPOSE:To automate the estimation of swallowing motion from 2D MR cine images using deformable registration for future applications of personalized margin reduction in head and neck radiotherapy and outcome assessment of radiation-associated dysphagia. METHODS:Twenty-one patients with serial 2D FSPGR-MR cine scans of the head and neck conducted through the course of definitive radiotherapy for oropharyngeal cancer. Included patients had at least one cine scan before, during, or after radiotherapy, with a total of 52 cine scans. Contours of 7 swallowing related regions-of-interest (ROIs), including pharyngeal constrictor, epiglottis, base of tongue, geniohyoid, hyoid, soft palate, and larynx, were manually delineated from consecutive frames of the cine scan covering at least one swallowing cycle. We applied a modified thin-plate-spline robust-point-matching algorithm to register the point sets of each ROI automatically over frames. The deformation vector fields from the registration were then used to estimate the motion during swallowing for each ROI. Registration errors were estimated by comparing the deformed contours with the manual contours. RESULTS:On average 22 frames of each cine scan were contoured. The registration for one cine scan (7 ROIs over 22 frames) on average took roughly 22 minutes. A number of 8018 registrations were successfully batch processed without human interaction after the contours were drawn. The average registration error for all ROIs and all patients was 0.36 mm (range: 0.06 mm- 2.06 mm). Larynx had the average largest motion in superior direction of all structures under consideration (range: 0.0 mm- 58.7 mm). Geniohyoid had the smallest overall motion of all ROIs under consideration and the superior-inferior motion was larger than the anterior-posterior motion for all ROIs. CONCLUSION:We developed and validated a deformable registration framework to automate the estimation of swallowing motion from 2D MR cine scans.

Dataset Information

Real-time MRI motion estimation through an unsupervised k-space-driven deformable registration network (KS-RegNet).

Publications

Real-time MRI motion estimation through an unsupervised k-space-driven deformable registration network (KS-RegNet).

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