Bronchiolitis obliterans syndrome after lung or haematopoietic stem cell transplantation: current management and future directions.

ABSTRACT: Bronchiolitis obliterans syndrome (BOS) may develop after either lung or haematopoietic stem cell transplantation (HSCT), with similarities in histopathological features and clinical manifestations. However, there are differences in the contributory factors and clinical trajectories between the two conditions. BOS after HSCT occurs due to systemic graft-versus-host disease (GVHD), whereas BOS after lung transplantation is limited to the lung allograft. BOS diagnosis after HSCT is more challenging, as the lung function decline may occur due to extrapulmonary GVHD, causing sclerosis or inflammation in the fascia or muscles of the respiratory girdle. Treatment is generally empirical with no established effective therapies. This review provides rare insights and commonalities of both co

SUBMITTER: Glanville AR 

PROVIDER: S-EPMC9309343 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature