Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes.

ABSTRACT:

Background

This study aims to investigate the potential association of peripheral inflammatory blood cell parameters with the incidence and progression of chronic kidney disease (CKD) in patients with diabetes.

Methods

The cross-sectional study included 1192 subjects with diabetes derived from one center. The cohort study included 2060 subjects with diabetes derived from another two centers followed up for 4 years. Logistic regression and Cox proportional hazards models were used to evaluate the association of peripheral inflammatory blood cell with CKD.

Results

In the cross-sectional study, neutrophil count performed best as an independent risk factor for CKD (odds ratio 2.556 [95% confidence interval 1.111, 5.879]) even after 1:1 case-control matching for age, gende

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9310049 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature