Ontology highlight
ABSTRACT:
SUBMITTER: Ahodantin J
PROVIDER: S-EPMC9310524 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Ahodantin James J Nio Kouki K Funaki Masaya M Zhai Xuguang X Wilson Eleanor E Kottilil Shyamasundaran S Cheng Liang L Li Guangming G Su Lishan L
JCI insight 20220708 13
Liver diseases have become a major comorbidity health concern for people living with HIV-1 (PLWH) treated with combination antiretroviral therapy (cART). To investigate if HIV-1 infection and cART interact to lead to liver diseases, humanized mice reconstituted with progenitor cells from human fetal livers were infected with HIV-1 and treated with cART. We report here that chronic HIV-1 infection with cART induced hepatitis and liver fibrosis in humanized mice, associated with accumulation of M2 ...[more]