Unknown

Dataset Information

0

Switchable DNA-Based Peroxidases Controlled by a Chaotropic Ion.


ABSTRACT: Here we demonstrate a switchable DNA electron-transfer catalyst, enabled by selective destabilization of secondary structure by the denaturant, perchlorate. The system is comprised of two strands, one of which can be selectively switched between a G-quadruplex and duplex or single-stranded conformations. In the G-quadruplex state, it binds hemin, enabling peroxidase activity. This switching ability arises from our finding that perchlorate, a chaotropic Hofmeister ion, selectively destabilizes duplex over G-quadruplex DNA. By varying perchlorate concentration, we show that the DNA structure can be switched between states that do and do not catalyze electron-transfer catalysis. State switching can be achieved in three ways: thermally, by dilution, or by concentration.

SUBMITTER: Hoog TG 

PROVIDER: S-EPMC9310614 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5707462 | biostudies-literature
| S-EPMC6803638 | biostudies-literature
| S-EPMC7481839 | biostudies-literature
| S-EPMC5714950 | biostudies-literature
| S-EPMC4448110 | biostudies-literature
| S-EPMC2536529 | biostudies-literature
| S-EPMC10138138 | biostudies-literature
| S-EPMC2840443 | biostudies-literature
| S-EPMC528821 | biostudies-literature
| S-EPMC6693819 | biostudies-literature