In pursuit of biomarkers for predicting susceptibility to activity-based anorexia in adolescent female rats.

ABSTRACT:

Objective

Identifying risk factors that contribute to the development of anorexia nervosa (AN) is critical for the implementation of early intervention strategies. Anxiety, obsessive-compulsive behavior, and immune dysfunction may be involved in the development of AN; however, their direct influence on susceptibility to the condition remains unclear. Here, we used the activity-based anorexia (ABA) model to examine whether activity, anxiety-like behavior, compulsive behavior, and circulating immune markers predict the subsequent development of pathological weight loss.

Method

Female Sprague-Dawley rats (n = 44) underwent behavioral testing before exposure to ABA conditions after which they were separated into susceptible and resistant subpopulations. Blood was sampled before

SUBMITTER: Milton LK 

PROVIDER: S-EPMC9311799 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature