Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective.

ABSTRACT: Selenium (Se) is an important trace element that mainly occurs in the form of selenocysteine in selected proteins. In prokaryotes, Se is also required for the synthesis of selenouridine and Se-containing cofactor. A large number of selenoprotein families have been identified in diverse prokaryotic organisms, most of which are thought to be involved in various redox reactions. In the last decade or two, computational prediction of selenoprotein genes and comparative genomics of Se metabolic pathways and selenoproteomes have arisen, providing new insights into the metabolism and function of Se and their evolutionary trends in bacteria and archaea. This review aims to offer an overview of recent advances in bioinformatics analysis of Se utilization in prokaryotes. We describe current computat

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9312934 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature