Benchmarking the Accuracy of AlphaFold 2 in Loop Structure Prediction.

ABSTRACT: The inhibition of protein-protein interactions is a growing strategy in drug development. In addition to structured regions, many protein loop regions are involved in protein-protein interactions and thus have been identified as potential drug targets. To effectively target such regions, protein structure is critical. Loop structure prediction is a challenging subgroup in the field of protein structure prediction because of the reduced level of conservation in protein sequences compared to the secondary structure elements. AlphaFold 2 has been suggested to be one of the greatest achievements in the field of protein structure prediction. The AlphaFold 2 predicted protein structures near the X-ray resolution in the Critical Assessment of protein Structure Prediction (CASP 14) competition in

SUBMITTER: Stevens AO 

PROVIDER: S-EPMC9312937 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature