Ontology highlight
ABSTRACT:
SUBMITTER: Pintado-Grima C
PROVIDER: S-EPMC9313257 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Pintado-Grima Carlos C Bárcenas Oriol O Ventura Salvador S
Biomolecules 20220712 7
Intrinsically disordered proteins (IDPs) are essential players in the assembly of biomolecular condensates during liquid-liquid phase separation (LLPS). Disordered regions (IDRs) are significantly exposed to the solvent and, therefore, highly influenced by fluctuations in the microenvironment. Extrinsic factors, such as pH, modify the solubility and disorder state of IDPs, which in turn may impact the formation of liquid condensates. However, little attention has been paid to how the solution pH ...[more]