Ontology highlight
ABSTRACT:
SUBMITTER: Koulouridi A
PROVIDER: S-EPMC9313302 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Koulouridi Asimina A Karagianni Michaela M Messaritakis Ippokratis I Sfakianaki Maria M Voutsina Alexandra A Trypaki Maria M Bachlitzanaki Maria M Koustas Evangelos E Karamouzis Michalis V MV Ntavatzikos Anastasios A Koumarianou Anna A Androulakis Nikolaos N Mavroudis Dimitrios D Tzardi Maria M Souglakos John J
Cancers 20220707 14
Colorectal cancer (CRC) remains a major public health issue. The detection of parameters that affect CRC prognosis is of great significance. <i>KRAS</i> mutations, play a crucial role in tumorigenesis with a strong predictive value. <i>KRAS</i>-mutated stage-IV CRC patients gain no benefit of the anti-EGFR therapy. The <i>KRAS</i> G12C mutation subtype is under investigation for treatment regimens. The present study aimed to detect various <i>RAS</i> mutations in a cohort of 578 <i>RAS</i>-mutat ...[more]