Ontology highlight
ABSTRACT:
SUBMITTER: Liang X
PROVIDER: S-EPMC9314316 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Liang Xiuming X Niu Zheyu Z Galli Valentina V Howe Nathalie N Zhao Ying Y Wiklander Oscar P B OPB Zheng Wenyi W Wiklander Rim Jawad RJ Corso Giulia G Davies Christopher C Hean Justin J Kyriakopoulou Eleni E Mamand Doste R DR Amin Risul R Nordin Joel Z JZ Gupta Dhanu D Andaloussi Samir El SE
Journal of extracellular vesicles 20220701 7
Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after administration could be a limitation in certain therapeutic settings. To solve this, an engineering strategy is employed to decorate albumin onto the surface of the EVs through surface display of albumin binding domains (ABDs). ABDs were either included in the extracellular loops of select EV-enriched tetraspanins (CD63, CD9 and CD81) or directly f ...[more]