Ontology highlight
ABSTRACT:
SUBMITTER: Hou J
PROVIDER: S-EPMC9314356 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Hou Jiahui J Hess Jonathan L JL Armstrong Nicola N Bis Joshua C JC Grenier-Boley Benjamin B Karlsson Ida K IK Leonenko Ganna G Numbers Katya K O'Brien Eleanor K EK Shadrin Alexey A Thalamuthu Anbupalam A Yang Qiong Q Andreassen Ole A OA Brodaty Henry H Gatz Margaret M Kochan Nicole A NA Lambert Jean-Charles JC Laws Simon M SM Masters Colin L CL Mather Karen A KA Pedersen Nancy L NL Posthuma Danielle D Sachdev Perminder S PS Williams Julie J Fan Chun Chieh CC Faraone Stephen V SV Fennema-Notestine Christine C Lin Shu-Ju SJ Escott-Price Valentina V Holmans Peter P Seshadri Sudha S Tsuang Ming T MT Kremen William S WS Glatt Stephen J SJ
Translational psychiatry 20220725 1
Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer's disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals having high PRSs for LOAD, and (2) unaffected APOE-ε4 carriers also having high PRSs for LOAD. We used genome-wide association study (GWAS) to contrast "resilient" unaffected individuals at the highest ...[more]