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Strategies discovery in the active allothetic place avoidance task.

ABSTRACT: The Active Allothetic Place Avoidance task is an alternative setup to Morris Water Maze that allows studying spatial memory in a dynamic world in the presence of conflicting information. In this task, a rat, freely moving on a rotating circular arena, has to avoid a sector defined within the room frame where shocks are presented. While for Morris Water Maze several studies have identified animal strategies which specifically affect performance, there were no such studies for the Active Allothetic Place Avoidance task. Using standard machine learning methods, we were able to reveal for the first time, to the best of our knowledge, explainable strategies that the animals employ in this task and demonstrate that they can provide a high-level interpretation for performance differences between an animal group treated with silver nanoparticles (AgNPs) and the control group.

SUBMITTER: Vouros A

PROVIDER: S-EPMC9314408 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Strategies discovery in the active allothetic place avoidance task.

Vouros Avgoustinos A Gehring Tiago V TV Jura Bartosz B Węsierska Małgorzata J MJ Wójcik Daniel K DK Vasilaki Eleni E

Scientific reports 20220725 1

The Active Allothetic Place Avoidance task is an alternative setup to Morris Water Maze that allows studying spatial memory in a dynamic world in the presence of conflicting information. In this task, a rat, freely moving on a rotating circular arena, has to avoid a sector defined within the room frame where shocks are presented. While for Morris Water Maze several studies have identified animal strategies which specifically affect performance, there were no such studies for the Active Allotheti ...[more]

PMID: 35879365

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