Unknown

Dataset Information

0

Persistence of parental-reported asthma at early ages: A longitudinal twin study.


ABSTRACT:

Background

Currently, we cannot predict whether a pre-school child with asthma-like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of pre-school to school-age asthma. We examined to what extent genetic and environmental factors contribute to persistence of asthma-like symptoms at ages 3 to asthma at age 7 using a bivariate genetic model for longitudinal twin data.

Methods

We performed a cohort study in monozygotic and dizygotic twins from the Netherlands Twin Register (NTR, n = 21,541 twin pairs). Bivariate genetic models were fitted to longitudinal data on asthma-like symptoms reported by parents at age 3 and 7 years to estimate the contribution of genetic and environmental factors.

Results

Bivariate genetic modeling showed a correlation on the liability scale between asthma-like symptoms at age 3 and asthma at age 7 of 0.746 and the contribution of genetics was estimated to be 0.917. The genetic analyses indicated a substantial influence of genetic factors on asthma-like symptoms at ages 3 and 7 (heritability 80% and 90%, respectively); hence, contribution of environmental factors was low. Persistence was explained by a high (rg = 0.807) genetic correlation.

Conclusion

Parental-reported asthma-like symptoms at age 3 and asthma at age 7 are highly heritably. The phenotype of asthma-like symptoms at age 3 and 7 was highly correlated and mainly due to heritable factors, indicating high persistence of asthma development over ages 3 and 7.

SUBMITTER: Slob EMA 

PROVIDER: S-EPMC9314674 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Persistence of parental-reported asthma at early ages: A longitudinal twin study.

Slob Elise Margaretha Adriana EMA   Longo Cristina C   Vijverberg Susanne J H SJH   Beijsterveldt Toos C E M van TCEMV   Bartels Meike M   Hottenga Jouke Jan JJ   Pijnenburg Mariëlle W MW   Koppelman Gerard H GH   Maitland-van der Zee Anke-Hilse AH   Dolan Conor V CV   Boomsma Dorret I DI  

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20220301 3


<h4>Background</h4>Currently, we cannot predict whether a pre-school child with asthma-like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of pre-school to school-age asthma. We examined to what extent genetic and environmental factors contribute to persistence of asthma-like symptoms at ages 3 to asthma at age 7 using a bivariate genetic model for longitudinal twin data.<h4>Methods</h4>We per  ...[more]

Similar Datasets

| S-EPMC3700929 | biostudies-literature
| S-EPMC5345554 | biostudies-literature
| S-EPMC7754341 | biostudies-literature
| S-EPMC5591640 | biostudies-literature
| S-EPMC11812261 | biostudies-literature
| S-EPMC3326005 | biostudies-literature
| S-EPMC6869380 | biostudies-literature
| S-EPMC6938629 | biostudies-literature
| S-EPMC5855313 | biostudies-literature
| S-EPMC2743740 | biostudies-other