A Secretory Vesicle Failure in Parkinson's Disease Occurs in Human Platelets.

ABSTRACT:

Objective

The presence of elevated dopamine (DA) and its major metabolites in the cytosol of neurons has been associated with their vulnerability in Parkinson's disease (PD). Over 99% of the cell's amines are confined to secretory vesicles (SVs), making these structures fundamental in the regulation of cytosolic DA levels. SVs of platelets use similar, if not the same mechanisms to accumulate serotonin in SVs as dopaminergic neurons do to store DA. Hence, any functional defects in platelets probably mirrors events in DA neurons.

Methods

We have isolated fresh platelets from the blood of 75 PD patients, 116 matched controls and 24 patients with Parkinsonism, assaying serotonin handling (basal content, accumulation, secretion and spontaneous leakage).

Results

We found a

SUBMITTER: Montenegro P 

PROVIDER: S-EPMC9315021 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature