Ontology highlight
ABSTRACT:
SUBMITTER: Zhan Q
PROVIDER: S-EPMC9318409 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Zhan Qiao Q Chang Le L Wu Jian J Zhang Zhiyuan Z Xu Jinghang J Yu Yanyan Y Feng Zhenru Z Zeng Zheng Z
Pathogens (Basel, Switzerland) 20220626 7
Antibodies in response to antigens are related to the immune repertoire of T- and B-cell receptors. However, some patients with chronic hepatitis B (CHB) have coexisting HBsAg and anti-HBsAg antibodies (anti-HBs) that cannot neutralize HBV. We attempted to investigate the repertoires that produce this response in CHB patients. The T-cell receptor β chain (TRB) and B-cell receptor (BCR) repertoires of peripheral blood genomic DNA were analyzed using MiXCR. T-cell receptor (TCR) cluster analysis w ...[more]