Ontology highlight
ABSTRACT:
SUBMITTER: Pang Y
PROVIDER: S-EPMC9318422 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Pang Yilin Y Liu Xinjie X Wang Xu X Shi Xuelian X Ma Lei L Zhang Yan Y Zhou Tiangang T Zhao Chenxi C Zhang Xu X Fan Baoyou B Hao Jian J Li Wenxiang W Zhao Xiaoqing X Zhang Rong R Zhou Songlin S Kong Xiaohong X Feng Shiqing S Yao Xue X
Frontiers in cell and developmental biology 20220518
The FDA-approved drug edaravone has a neuroprotective effect on spinal cord injury (SCI) and many other central nervous system diseases. However, its molecular mechanism remains unclear. Since edaravone is a lipid peroxidation scavenger, we hypothesize that edaravone exerts its neuroprotective effect by inhibiting ferroptosis in SCI. Edaravone treatment after SCI upregulates glutathione peroxidase 4 (GPX4) and system Xc-light chain (xCT), which are anti-ferroptosis proteins. It downregulates pro ...[more]