Ontology highlight
ABSTRACT:
SUBMITTER: Courlet P
PROVIDER: S-EPMC9322950 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Courlet Perrine P Cardoso Evelina E Bandiera Carole C Stravodimou Athina A Zurcher Jean-Philippe JP Chtioui Haithem H Locatelli Isabella I Decosterd Laurent Arthur LA Darnaud Léa L Blanchet Benoit B Alexandre Jérôme J Wagner Anna Dorothea AD Zaman Khalil K Schneider Marie Paule MP Guidi Monia M Csajka Chantal C
Pharmaceutics 20220621 7
Neutropenia is the most frequent dose-limiting toxicity reported in patients with metastatic breast cancer receiving palbociclib. The objective of this study was to investigate the pharmacokinetic-pharmacodynamic (PK/PD) relationships for toxicity (i.e., absolute neutrophil count, ANC) and efficacy (i.e., progression-free survival, PFS). A semi-mechanistic PK/PD model was used to predict neutrophils' time course using a population approach (NONMEM). Influence of demographic and clinical characte ...[more]