Ontology highlight
ABSTRACT:
SUBMITTER: Gill MR
PROVIDER: S-EPMC9323417 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Gill Martin R MR Jarman Paul J PJ Hearnden Vanessa V Fairbanks Simon D SD Bassetto Marcella M Maib Hannes H Palmer John J Ayscough Kathryn R KR Thomas Jim A JA Smythe Carl C
Angewandte Chemie (International ed. in English) 20220503 27
The dinuclear Ru<sup>II</sup> complex [(Ru(phen)<sub>2</sub> )<sub>2</sub> (tpphz)]<sup>4+</sup> (phen=1,10-phenanthroline, tpphz=tetrapyridophenazine) "RuRuPhen" blocks the transformation of G-actin monomers to F-actin filaments with no disassembly of pre-formed F-actin. Molecular docking studies indicate multiple RuRuPhen molecules bind to the surface of G-actin but not the binding pockets of established actin polymerisation inhibitors. In cells, addition of RuRuPhen causes rapid disruption to ...[more]