Dataset Information

Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.

ABSTRACT:

Objective

We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries.

Methods

Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis.

Results

Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs.

Conclusion

Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.

SUBMITTER: Buchanan J

PROVIDER: S-EPMC9325352 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.

Buchanan James J Buchanan James J Hill Melissa M Vass Caroline M CM Hammond Jennifer J Riedijk Sam S Klapwijk Jasmijn E JE Harding Eleanor E Lou Stina S Vogel Ida I Hui Lisa L Ingvoldstad-Malmgren Charlotta C Soller Maria Johansson MJ Ormond Kelly E KE Choolani Mahesh M Zheng Qian Q Chitty Lyn S LS Lewis Celine C

Prenatal diagnosis 20220430 7

<h4>Objective</h4>We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries.<h4>Methods</h4>Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women fro ...[more]

PMID: 35476801

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Dataset Information

Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.

Objective

Methods

Results

Conclusion

Publications

Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.

Similar Datasets

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