The Cerebellar Gene Database: a Collective Database of Genes Critical for Cerebellar Development.

ABSTRACT: This report presents the first comprehensive database that specifically compiles genes critical for cerebellar development and function. The Cerebellar Gene Database details genes that, when perturbed in mouse models, result in a cerebellar phenotype according to available data from both Mouse Genome Informatics and PubMed, as well as references to the corresponding studies for further examination. This database also offers a compilation of human genetic disorders with a cerebellar phenotype and their associated gene information from the Online Mendelian Inheritance in Man (OMIM) database. By comparing and contrasting the mouse and human datasets, we observe that only a small proportion of human mutant genes with a cerebellar phenotype have been studied in mouse knockout models. Given the

SUBMITTER: Ramirez M 

PROVIDER: S-EPMC9325837 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature