Extraversion Is Associated With Lower Brain Beta-Amyloid Deposition in Cognitively Normal Older Adults.

ABSTRACT: Emerging evidence suggests that some personality traits may link to the vulnerability to or protection for Alzheimer's disease (AD). A causal mechanism underlying this relationship, however, remains largely unknown. Using ¹⁸F-Florbetaben positron emission tomography (PET) binding to beta-amyloid (Aβ) plaques, a pathological feature of AD, and functional magnetic resonance imaging (fMRI), we investigated pathological and functional correlates of extraversion and neuroticism in a group of healthy young and older subjects. We quantified the level of brain Aβ deposition in older individuals. Brain activity was measured in young adults using a task-switching fMRI paradigm. When we correlated personality scores of extraversion and neuroticism with these pathological and functional mea

SUBMITTER: Oh H 

PROVIDER: S-EPMC9325961 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature