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Visible-Light-Promoted Transition-Metal-Free Construction of 3-Perfluoroalkylated Thioflavones

ABSTRACT: A visible-light-promoted transition-metal-free perfluoroalkylation/cyclization reaction was developed with 9-mesityl-10-methylacridinium perchlorate (Acr+-Mes·ClO4−) as the photocatalyst, by which various perfluoroalkyl-substituted heterocycles including thioflavones, oxindoles, and quinoline-2,4(1H,3H)-diones were prepared at room temperature. Moreover, the potential of this sustainable method is demonstrated by the excellent in vitro anti-lymphoma and cervical carcinoma activity of the novel 3-perfluoroalkylated thioflavone 3m.

SUBMITTER: Ma C

PROVIDER: S-EPMC9326344 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Visible light-promoted metal-free sp(3)-C-H fluorination.

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