Unknown

Dataset Information

0

Noradrenergic Signaling in Astrocytes Influences Mammalian Sleep Homeostasis.


ABSTRACT: Astrocytes influence sleep expression and regulation, but the cellular signaling pathways involved in these processes are poorly defined. We proposed that astrocytes detect and integrate a neuronal signal that accumulates during wakefulness, thereby leading to increased sleep drive. Noradrenaline (NA) satisfies several criteria for a waking signal integrated by astrocytes. We therefore investigated the role of NA signaling in astrocytes in mammalian sleep. We conditionally knocked out (cKO) β2-adrenergic receptors (β2-AR) selectively in astrocytes in mice and recorded electroencephalographic and electromyographic activity under baseline conditions and in response to sleep deprivation (SDep). cKO of astroglial β2-ARs increased active phase siesta duration under baseline conditions and reduced homeostatic compensatory changes in sleep consolidation and non-rapid eye movement slow-wave activity (SWA) after SDep. Overall, astroglial NA β2-ARs influence mammalian sleep homeostasis in a manner consistent with our proposed model of neuronal-astroglial interactions.

SUBMITTER: Ingiosi AM 

PROVIDER: S-EPMC9326550 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9588578 | biostudies-literature
| S-EPMC5736401 | biostudies-literature
| S-EPMC7550187 | biostudies-literature
| S-EPMC8108464 | biostudies-literature
| S-EPMC3741064 | biostudies-literature
| S-EPMC7138839 | biostudies-literature
| S-EPMC6226024 | biostudies-literature
| S-EPMC9255708 | biostudies-literature
| S-EPMC4355896 | biostudies-other
| S-EPMC9674092 | biostudies-literature